Medication delivery systems and methods

ABSTRACT

The present disclosure relates to a medication delivery system including a medication administration device, a medication within the medication administration device, a container defining a cavity receiving the medication administration device, and a cap attached to the container and sealing the medication administration device within the cavity. The medication administration device includes an actuator extending from a body and operable to expel the medication by depressing the actuator into the body. The cap includes hold down members positioned to bear against the body of the medication administration device to prevent movement of the medication administration device toward the cap beyond a predetermined distance. The medication administration device is thereby prevented, inter alia, from prematurely discharging the medication during storage and transport.

TECHNICAL FIELD

This disclosure relates to medication delivery systems which provide formaintaining a medication administration device and contained medicationin a viable condition. The disclosure further pertains to medicaldelivery systems in which the medication administration device may bequickly and easily removed from the container assembly for use.

BACKGROUND

Medication systems including medication administration devices withcontained medications need to be maintained in proper conditions fromthe time the medication administration device is filled with themedication to eventual use by a patient. There is a particular need forsuch delivery systems which enhance the viability of pre-filledmedication administration devices during storage and transport.Medication administration devices of this type are susceptible to avariety of quality issues. For example, the US Food and DrugAdministration (FDA) recently issued draft guidance on qualityconsiderations for aerosol drug delivery systems. See,wwwfda.gov/downloads/Drugs/GuidanceComplianceRegulatoryInformation/Guidances/UCM070573.pdf(April, 2018). The guidance provides recommendations for the developmentand manufacture of aerosols. The guidance addresses quality profilesthat include elements such as stability, dosage form, aerodynamicperformance, and the delivery system. All of these aspects impact theutility of the dispensed medication.

In a particular aspect, the disclosed medication delivery system is usedin connection with the delivery of glucagon. Normally, glucagon isproduced in the pancreas and works with insulin to regulate bloodglucose levels in the body. Glucagon is released in the body when bloodglucose levels are low, signaling the liver to release glucose into theblood. People with diabetes either no longer produce insulin (Type 1) ortheir bodies are less able to respond to insulin (Type 2).

Both the medication administration device and the medication need to beprovided in a manner that materially enhances the safety and efficacy ofthe dispensed medication. The medication may be provided with a stableenvironment to maintain proper moisture content, aerodynamic particlesize distribution, and/or activity. The medication administration devicemay be maintained under proper conditions. Medication administrationdevices can be retained in a hermetically sealed enclosure prior to use.This can inhibit contact with moisture, foreign particulate matter,impurities, degradants, and other deleterious materials which mightimpair the proper functioning of the medication administration device.The medication administration devices should also be protected fromphysical damage and premature actuation.

While insulin and insulin pumps have evolved into highly technical andeffective tools for treating diabetes, the methods for deliveringemergency glucagon to save the lives of people with diabetesexperiencing hypoglycemia have not progressed as far as desirable.Reconstituting powdered glucagon and injecting it can be difficult, andoften the person with diabetes needs assistance. A simple nasal sprayallows glucagon to be administered quickly and easily in a rescuesituation.

For those with Type 1 diabetes (T1D), too much insulin can limit thebody's ability to release glucagon as blood glucose levels fall; thus,if the person with T1D is unable to eat or drink sugar, treatment withglucagon is needed to bring blood glucose levels back into balance.Severe hypoglycemia can lead to hospitalization or even death in extremecases. Maintaining the integrity of both the glucagon and its deliverydevice is therefore understood to be of great importance.

SUMMARY

In accordance with an aspect of the present disclosure, a medicationdelivery system is provided which comprises a medication administrationdevice, medication received within the medication administration device,a container defining a cavity to receive the medication administrationdevice, and a cap to seal the medication administration device withinthe container. The medication administration device is of a type inwhich an actuator extends from a body and is movable from the extendedposition to a depressed position to expel the medication. The containerdefines an access opening to a cavity into which the medicationadministration device is placed. A cap is secured to the container inthe closed position to form a hermetic sealing of the medicationadministration device within the cavity. The cap includes one or morehold down members which are position to prevent the medicationadministration device from moving against the cap.

In another aspect, a training system includes a training module that isconfigured to simulate the medication delivery device, but does notcontain a medication product, and/or a training container configured tosimulate operation of the product container.

It is an object to provide a cap and container assembly which provides asecure and sealed enclosure for the medication administration device,while also including components which prevent premature discharge of themedication.

Another object is to provide a medication delivery system which containsa medication administration device in a manner that the medicationadministration device can be readily and quickly removed from acontainer for use.

Methods for the containment of medication administration devices in amanner to maintain the operability of the medication administrationdevice and the viability of the contained medication are also disclosed.

Other objects and advantages of the disclosed medication delivery systemwill be apparent to those of ordinary skill in the art.

BRIEF DESCRIPTION OF THE DRAWINGS

The features and advantages of the present disclosure will become moreapparent to those skilled in the art upon consideration of the followingdetailed description taken in conjunction with the accompanying figures.

FIG. 1 is a perspective view of components useful in conjunction with amedication delivery system, depicting a medication administration deviceand a container in a side-by-side relationship.

FIG. 2 is a perspective view of an embodiment of the medication deliverysystem, depicting the device inserted within the container with the capin an open position.

FIG. 3 is a side, cross-sectional view of the container of themedication delivery system of FIG. 2 with the device inserted.

FIG. 4 is a side, elevational view of the medication delivery system ofFIG. 2, showing the hinged connection of the cap with the container.

FIG. 5 is a side, elevational view of the container with the cap in aclosed position, showing additional details of a living hinge.

FIG. 6 is a partial perspective view of the medication delivery systemshown in FIG. 2, showing details of a latch mechanism of the containerand the cap.

FIG. 7 is a side, partial cross-sectional view of the container of themedication delivery system, showing the cap in the closed positionsealed with the container with the device inserted therein.

FIG. 8 is a partial, cross-sectional view of the container, showing theinterior of the container with a desiccant plug.

FIG. 8a is a detailed view of the desiccant plug retention mechanismfrom FIG. 8.

FIG. 9 is a perspective view of a training container with its cap in theopen position.

FIG. 10 is a side, cross-sectional view of the training container shownin FIG. 9 with its cap in the closed position.

DETAILED DESCRIPTION

For the purposes of promoting an understanding of the principles of thepresent disclosure, reference will now be made to the embodimentsillustrated in the drawings, and specific language will be used todescribe the same. It will nevertheless be understood that no limitationof the scope of the invention is thereby intended.

In one aspect there are disclosed intranasal delivery systems comprisinga medication administration device for dispensing a medication. Suchmedication administration devices typically include a body containing amedication reservoir communicating through a discharge port, and anactuator mechanism for expelling the medication through the dischargeport. The discharge port is sealed prior to use. The actuator isoperable to unseal the discharge port and cause delivery of themedication. A common configuration for such a medication administrationdevice includes an actuator that extends from the body prior to deliveryof the medication. Moving the actuator from the extended position to adepressed position unseals the discharge port and releases themedication.

In an embodiment, there is disclosed a medication delivery systemcomprising a medication administration device, medication receivedwithin the medication administration device, a container receiving themedication delivery system, and a cap sealing the medication deliverysystem within the container. In another embodiment, there is provided amethod for containing a medication administration device in a sealedcondition protecting a contained medication. In yet another embodiment,there is provided a container assembly for a medication administrationdevice including a container having an internal cavity for receiving themedication administration device, and a cap attached to the containerand sealing the internal cavity in a closed position.

Referring to FIG. 1, there is shown an exemplary medication deliverysystem 10 comprising a medication administration device 12 containing amedication (not shown), a container 14 for receiving medicationadministration device 12, and a cap 16 for sealing container 14.Medication administration device 12 comprises a body 18 disposedgenerally longitudinally along a device axis DA, having a discharge end20 and an opposed actuator end 22. The medication administration deviceincludes a medication reservoir defined by body 18 and containing amedication to be dispensed from the medication administration device.The medication is dispensed through a medication discharge port 24 whichcomprises an opening communicating with the medication reservoir.

Medication administration device 12 further includes an actuator 26 forejecting the medication from the reservoir through discharge port 24.Actuator 26 extends out of the actuator end of body 18. Actuator 26further is linearly movable from an extended position shown in FIG. 1 toa depressed position (not shown). Medication discharge port 24 is sealedfrom communication with the medication reservoir when actuator 26 is inthe extended position to retain the contained medication in a sealedcondition. Actuator 26 is operable to discharge medication from thereservoir upon axial movement from the extended position to thedepressed position. During such movement, communication between thedischarge port and the reservoir is provided to allow for dispensing ofthe medication.

Also shown in FIG. 1 are the container 14 and cap 16. Container 14 has atubular side wall 28 disposed longitudinally along a container axis CA.Side wall 28 is closed by bottom wall 30 at one end to define a cavity32 within container 14. The opposed end provides an access opening 34defined by end wall portion 36. Cavity 32 is sized and configured toreceive medication administration device 12 with discharge end 20adjacent bottom wall 30. Side wall 28 may generally define a cylindricalshape.

Cap 16 is sized and configured to mate with container 14 in the closedposition to provide a hermetic seal enclosing cavity 32 for medicationadministration device 12 when received therein. Cap 16 includes one ormore hold down members (described later with reference to FIG. 2)positioned and configured to bear against a non-actuator portion of body18 of medication administration device 12. The one or more hold downmembers retain the medication administration device in the cavity 32without pressure being applied to actuator 26 while cap 16 is in theclosed position. In particular, each of the hold down members comprisesa projection extending from cap 16 toward bottom wall 30. In oneexample, each of the hold down members is formed integrally from thesame material with the cap using a molding process. In other examples,the hold down members may be formed separately and bonded or otherwisesecurely fixed to the cap. The hold down members may be made from amaterial that provides a rigid structure. In one example, rigid holdmembers are configured to maintain their relative orientation andpositioning relative to the cap (and each other if more than one) andthe non-actuator portion of body 18 of medication administration device12 to avoid movement of the ends of the hold down members to anundesirable position that could cause premature actuation of the device.A rigid hold member can maintain its relative axial position and radialposition of the members ends relative to the cap and the device.

Medication administration device 12 is shown received within container14 in FIGS. 2-3. Actuator 26 is shown extending axially out of body 18of medication administration device 12. At least an end portion 38 ofactuator 26 extends beyond the plane of end wall portion 36. Cap 16 mayinclude a cup shaped body 39 having a cap side wall 41 that defines arecess 40 receiving end portion 38 of actuator 26. The cup shaped body39 of cap 16 may include a radially outward rim portion 66.

In FIG. 2, body 18 of medication administration device 12 includes acircumferential surface 42 surrounding, and coaxial with, actuator 26about device axis DA and facing in the direction away from bottom wall30. The hold down members 44 are shown in FIGS. 2-3 to be axiallyextending along the container axis CA when the cap is in the closedposition. In one embodiment, there are two hold down members 44extending from cap 16. The hold down members are configured to have endcontact surfaces 46 positioned to bear against circumferential surface42, representing the non-actuator portion, that is radially outside andclear of the actuator, in the event that medication administrationdevice 12 is urged to move axially in a direction away from bottom wall30. With a rigid hold member, the end contact surface 46 maintains itsrelative axial position and radial position relative to the cap and thecircumferential surface 42 of the device. Movement of the end contactsurface 46 from a structure having a spring configuration may permit theend contact surfaces to inadvertently cause premature actuation of thedevice. In one embodiment, shown in FIG. 7, an interior surface 41 a ofthe cap side wall 41 and an interior surface 44 a of the hold downmembers 44 define a continuous surface, and in some instances, acontinuously smooth surface. The hold down members 44 may include asupport rib along the radially outer surface of the hold down member.Other portions of the device may be used as the non-actuator portionthat is contacted by the hold down members.

The relative positioning of the components is evident in FIG. 3. The oneor more hold down members are provided to prevent the medicationadministration device from moving away from bottom wall 30 a distancethat would cause end portion 38 of actuator 26 to bear against theinterior axial surface 48 of cap 16. If such contact was allowed, itwould be possible for the medication administration device to be damagedor to prematurely discharge the medication.

The one or more hold down members are positioned and configured tointerfere with movement of the medication administration device to allowat most a predetermined amount of movement of the medicationadministration device in the direction away from bottom wall 30 andtoward cap 16. It is not required that end contact surfaces 46 beengaged with circumferential surface 42 at all times. Rather, a slightgap can be provided between end contact surfaces 46 and circumferentialsurface 42 when the components of the medication delivery system are inan at rest position. If an external force is applied that would causemedication administration device 12 to move away from bottom wall 30,then the contact surfaces 46 of hold down members 44 serve as an endstop to such movement.

In this respect, as shown in FIG. 3, a small gap is provided between thecontact surfaces 46 and the surface 42 of body 18. There is also alarger gap between the end surface 47 of end portion 38 and the interiorsurface 48 of cap 16. This relative sizing of the two gaps prevents theinterior surface 48 from contacting the actuator 26. The smaller gapmay, for example, be between 0.1 mm and 1.865 mm.

With reference FIGS. 4-5, cap 16 may be joined to container 14 with ahinged connection 50. Connection 50 may be in the form of a “livinghinge” comprising a continuous material bridge 52 integrally connectingcap 16 and container 14. FIG. 5 shows an external view regarding thehinged connection. An enlarged, axially-extending portion 54 of sidewall 28 extends to end wall portion 36 to provide a living hinge 52.Portion 54 is flat, instead of matching the radius of wall 28. If thehinge is not straight, it will result in high stress on the ends of thehinge. This hinge design is intended to minimally vary the shape of theoutside of the container for improved appearance. Other common hingeswould result in a portion of the hinge protruding from wall 28. In thisembodiment the cap and container are formed as one integral piece suchas by injection molding.

Various embodiments of suitable hinges are known. For example, in analternative embodiment the hinge comprises an axle-like member extendinghorizontally along the outside of the container. The axle is held at aposition spaced from the exterior of the container wall, such as by apair of outwardly extending flanges. In this embodiment, the capincludes a partially-cylindrical member that is received over and pivotsaround the axle. Alternatively, these structures may be reversed withthe cap including the pivot axle and the container including thecylindrical component. In these alternate embodiments the cap andcontainer would be formed separately and assembled together.

The two hold down members are disposed circumferentially away from oneanother, and the hinged connection 50 is disposed circumferentiallybetween the two hold down members (44). In an exemplary embodiment, cap16 includes two hold down members 44 positioned in opposed orthogonalpositions, that is, about ninety degrees, relative to hinged connection50. This provides two points of contact between hold down members 44 andbody 18. The hold down members may extend from the cup shape body of thecap at radially opposite sides of the cap. In some examples, this can bediametrically opposite. In other examples, need not be directly radiallyopposite, but can be offset by, for example, 150 degrees. The relativepositioning of the hold down members also makes it easier for the holddown members to “clear” side wall 28 and actuator 26 as cap 16 is movedbetween an open position and a closed position. However, it will beappreciated that any number and positioning of hold down members 44 maybe used. It will also be appreciated that cap 16 need not be hingedlyconnected to container 14, and that in itself may require or allowdifferent configurations of one or more hold down members.

In another exemplary embodiment, the cap includes a hinge joining thecap to the container. In one aspect, the cap only includes a single holddown member which can be disposed along any position from the interiorof the cap. In one embodiment, the single hold down member is positionedinterior of and radially aligned with the hinge, providing a goodcontainment of the medication delivery device within the container. Inanother embodiment, the single hold down member may be positioned ineither location of any one of the hold down members shown in, forexample, FIG. 2, or, for example, positioned in the location of the oneshown in FIG. 9.

Alternatively, cap 16 may be fully detachable from container 14.However, an advantage of the hinged connection is that it facilitatesattachment and removal of cap 16. It also orients the hold down membersin a desirable position relative to container 14.

Regardless of the manner of attachment of cap 16 with container 14 inthe closed position, the provision of the hold down members as a part ofthe cap provides distinct advantages. Hold down members 44 are madeavailable to retain the medication administration device while attachedto the cap that is removed when the medication administration device isneeded. Therefore, the removal of cap 16 also results in a removal ofthe hold down members, without requiring a separate action to unlock themedication administration device from the container. This allows forquick and easy removal of the medication administration device from thecontainer. Although not required, the hold down members may also beprovided as an integral component of cap 16, which facilitatesproduction of the hold down members and avoids additional productionsteps and costs if provided as a separate component.

Referring to FIG. 6, it is shown that the medication delivery system mayinclude a locking mechanism 56 to hold cap 16 in the closed positionwith container 14 in the absence of an intended separation of the twocomponents. Any such locking mechanism may be used that providessufficient security to hold the components in a locked condition, whilealso permitting a reasonable release of the locking mechanism whendesired. In one embodiment, locking mechanism 56 comprises mating latchmembers or latching mechanism. Latch 58 is attached to cap 16 andextends axially along the container axis when cap 16 is in the closedposition. In this position, latch 58 is positioned to be receivedadjacent an exterior surface 60 of side wall 28. Latch 58 includes apair of apertures 62. A pair of complementary nubs 64 is formed inexterior surface 60 and are positioned to be received within apertures62 when cap 16 is placed in its closed position. The latch componentsand supporting members are sufficiently flexible and resilient for thelatch to be opened and closed as required.

Alternative locking and sealing mechanism may also be used. For example,in one embodiment the cap is snap fit with the container. In anotherembodiment, the cap is secured to the container by a press fit.

Latch 58 may be attached to and depending from an underneath surface ofthe rim portion 66 of cap 16, as shown in FIG. 2. This allows for theplacement of latch 58 to be received adjacent the exterior surface 60 ofside wall 28. The radial extent of the rim portion 66 away from theouter surface of the cup shaped body of the cap may be constant. In oneexample, the radial extent of the rim portion 66 may vary, such as, forexample, where the portion 67 of the rim portion 66 that is adjacent thelatch 58, may be is radially extended farther than the portion of therim portion 66 outside of the latch. Extended portion 67 may also serveas a thumb tab to facilitate removal of cap 16 from access opening 34 ofcontainer 14. The underneath surface of extended portion 67 may define athumb contact tab to provide an outwardly-extending surface which may bepressed up and away from container 14 to facilitate removal of the capfrom the container. User applies an axial force to the portion 67 tocause portion 67 to pivot due to flexible of material, thereby movingthe latch 58 in a manner such that the latch apertures 62 are removedfrom nubs 64 and the latch 58 clears the nubs 64 to permit the cap tomove to its open position.

The medication delivery system is configured to maintain the integrityof the medication administration device and medication from the timethey are sealed within the cap and container assembly until themedication administration device is removed and used to dispense themedication. The cap and container are provided with complementarysealing components to ensure a hermetic seal between them. Referring toFIGS. 6 and 7, container 14 includes end wall portion 36 defining accessopening 34. Cap 16 includes a circumferential sealing member comprisingperipheral axially extending flange 68 which is sized and configured toextend along and closely mate with the interior surface of end wallportion 36 to provide a hermetic seal enclosing the medicationadministration device in the cap 16 and container 14 assembly. Capsealing flange 68 extends axially along the container axis CA and isdisposed spaced radially inward from the latch 58 to define a gap forreceiving the radial thickness of end wall portion 36. Thecircumferential sealing flange 68 may depend axially from an underneathsurface of the rim portion 66. The hold down members 44 are disposedspaced radially inward relative to the flange 68, as shown in FIG. 7.The hold down members 44 are sized to extend axially beyond the bottomwall facing end surface of the flange 68. Flange 68 is shown extendingaxially beyond the latch 58 of the latching mechanism. A shorter latchrelative to the flange wall may reduce the cap opening forces. Latch 58is shown disposed circumferentially between the two hold down members44, but across the recess and radially opposite to the hinged connection50. Hold down members 44 may be about 180 degrees apart, and latch 58and hinged connection 50 may be about 180 degrees apart.

The materials used in the cap and container are of a type well known inthe art. The materials must provide the desired sealing function. If aliving hinge, latch or other features are included, the materials musthave sufficient strength, elasticity and resilience to fulfill thefunctional requirements. A wide variety of materials suitable for use incontainer 14 and cap 16 are known in the art, and typically includeplastics, particularly thermoplastics such as polypropylene andpolyethylene

Many medications are adversely affected by contact with deleteriouslevels of moisture. In one embodiment, the medication delivery systemcontains a moisture sensitive medication and container 14 and/or cap 16includes a desiccant. Referring to FIG. 8, there is shown a desiccantplug 70 received within container 14. The desiccant plug is configuredto fit within container 14 adjacent bottom wall 30, and has an annularshaped body provided with a central cavity 71 to receive medicationdischarge port 24 of medication administration device 12.

The desiccant plug may be formed, for example, as an injection moldedplug of a molecular sieve type, using known materials to absorb moisturethat may otherwise degrade the medication. The desiccant plug is sizedto comprise enough material to provide sufficient absorption ofmoisture. For this purpose the desiccant plug may be configured tosubstantially fill cavity 32 between medication administration device 12and the interior of side wall 28 of container 14.

Desiccant plug 70 may be secured within cavity 32 by various means, suchas an interference fit. Container 14 may also include a snap fitretention feature in which a radially inward projecting continuous ringor continuous interior shoulder 72 extending from an interior surface ofthe side wall of the container engages with the axial end surface ofdesiccant plug 70 once it has been moved a sufficient distance intocavity 32. The desiccant plug 70 may include an annular notch 73 definedalong a radially outer surface 75 of the desiccant body, which is shownformed at the intersection of the cap facing axial planar surface 77 ofthe desiccant body and the radially outer surface of the desiccant body.The annular notch 73 is sized and configured to receive the shoulder 72when the desiccant is disposed within the container, such as shown inFIG. 8a . Alternatively, the shoulder 72 may be operable to retain anannular shaped desiccant by engaging the cap facing axial planar surface77 of the desiccant body without the desiccant having the notch 73.

The disclosed medication delivery systems have application, inter alia,with medication administration devices that are pre-filled and provide amedication in dosage form. In particular, the medication administrationdevices may comprise dispersion devices which, as used herein, areconsidered to be devices which deliver a medication in a dispersed form,such as in metered aerosol or spray devices. These medicationadministration devices are pre-filled with the medications in a finisheddosage form. Embodiments include devices such as referenced in 68 Fed.Reg. 36,675, 36,676 and 36,680 (Jun. 18, 2003). Exemplary embodimentsinclude intranasal aerosol and spray devices.

The medication delivery systems may comprise a wide range of medicationadministration devices and medications. The medication delivery systemis particularly well suited for use with medication administrationdevices which are used for administration of powder medications, such asintranasal delivery powders. The medications may be any that can bedelivered by the dispersion devices. The medications may be associatedwith one or more other ingredients, as referenced, for example, at 21CFR § 314.3.

In an exemplary embodiment, the medication is glucagon. A medicationadministration device has been developed that provides for the deliveryof glucagon in a simple, one-use nasal powder. This provides significantadvantages over complicated systems that involve mixing liquid andpowder together and then injecting the solution. The use of thismedication administration device has been determined to bring bloodsugar levels close to normal within 30 minutes of taking the powderedglucagon.

In an embodiment, the medication is intranasal AMG504-1 product (LocemiaSolutions) containing 2 mg glucagon in 20 mg dry powder or 3 mg glucagonin 30 mg dry powder, depending on the dose. The nasal powder isadministered with a single-use, one-step dispensing device. The tip ofthe device is inserted in one nostril, and the dose is delivered bysimply depressing an actuator connected to a piston that discharges thepowder into the nostril. No cooperative measure is required from thepatient, as absorption takes place through the nasal mucosa. Theglucagon formulation is provided in the medication delivery system asdisclosed herein, resulting in a highly effective protection for theviability of both the glucagon and its delivery device.

It is sometimes desirable to provide a training device that allowspotential users the opportunity to become familiar with the manner ofusing a commercial form of a medication delivery system. In one aspect,a modified version of the described medication delivery system isprovided which has the same basic structures and functions as thecommercial device. However, it is also important that it is not possibleto confuse the training device with the commercial device as thetraining device need not be provided with the same level of refinement.For example, the commercial device is designed to provide a tight sealwhen the lid is closed upon the container, which is not required for atraining device.

Accordingly, the training device is designed in a manner to precludeinterchange of parts with the commercial device. For example, thetraining medication delivery device is configured to prevent itsplacement inside the commercial container and/or cap. Conversely, thetraining container and/or cap are configured to preclude reception ofthe commercial medication delivery device.

In one example, the training device may be sized such that its containerand/or cap define a cavity that is too short and/or too narrow toreceive the commercial medication device. Similarly, the trainingmedication delivery device may be designed to have a dimension that isnot able to be received within the cavity defined by the commercialcontainer and/or cap. It will be appreciated that the container, capand/or medication delivery device for the training device and thecommercial device may be made incompatible in various other ways.

Referring to FIGS. 9 and 10, there is shown an exemplary trainingcontainer and cap assembly. Container 74 comprises a cylindrical bodyincluding a grid 76 simulating the space occupied by desiccant plug 70of the prior embodiment. A pair of arms 78 extend outwardly from the topof container 74 and support a hinge pin 80. Cap 82 includes a cup shapedportion 84 defining a channel in which hinge pin 80 is received. Cupshaped portion 84 is formed from a material that is sufficientlyflexible as to allow it to be pressed onto hinge pin 80. The combinationof the cup shaped portion 84 received over hinge pin 80 provides a hinge86 connecting cap 82 and container 74.

Container 74 further includes a ridge 88 along the top edge of container74 in a position opposed to hinge 86. Ridge 88 extends transverse ofcontainer 74 and has a slightly convex shape as viewed in cross section.See FIG. 10. Cap 82 includes a flange 90 positioned to be engaged byridge 88 when cap 82 is in the closed position.

Cap 82 further includes a single hold down member 92 aligned with hinge86. Hold down member 92 includes a T-shaped end surface 94 positioned toprevent upward displacement of a simulated administration devicereceived in container 74.

Container 74 and cap 82 thereby form a receptacle having variations fromthe design of the earlier described embodiment. Cap 82, for example,demonstrates a design having a single hold down member, rather than thepair of hold down members 44. Hinge 86 and flange 90 representalternative designs to the living hinge and latch of the earlierembodiment.

In one aspect, there is provided a medication delivery system comprisingtwo different container and cap assemblies constituting a product systemand a training system. The product system is used to contain amedication administration device containing a medication to be deliveredto a patient. The training system is used to allow the patient to becomefamiliar with the structures and function of the product system.Instead, it only serves the purpose of allowing a patient to manipulatethe training module relative to the container and cap assembly of thetraining system to learn how the product assembly operates.

The embodiments of FIGS. 2 and 9 are representative of this overallmedication delivery system. By way of example, the embodiment of FIG. 2may serve as the product system and the embodiment of FIG. 9 may serveas the training system.

To obtain maximum effect, the training system includes a training modulethat simulates the medication delivery device, but does not contain amedication product. However, the training module is configured tooperate with the container and cap assembly of the training system insubstantially the same as a medication administration device isconfigured to operate with the contain and cap assembly of the productsystem.

Thus, the training module may comprise a body having a discharge enddefining a simulated medication discharge port and an opposed actuatorend including a simulated actuator. The actuator extends out of theactuator end of the body, and the actuator being linearly moveable froman extended position to a depressed position. The training module isconfigured to be similar to the medication delivery device, although itneed not be fully functional, e.g., it need not include an operatingactuator. The training container and cap assembly similarly isconfigured to simulate the container and cap assembly of the productsystem, but it need not be fully functional, e.g., containing adesiccant.

As previously noted, the components of the product and training systemsare configured such that the medication administration device isincompatible with the training container and cap assembly, and thetraining module is incompatible with the product container and capassembly. This may be accomplished in a variety of ways. For example,the training module may be provided with an outer diameter that does notfit within the container of the product system. Alternatively, thecontainer of the training system may be made to be too short for themedication administration device such that the cap cannot be closed overthe medication administration device. In general, it is sufficient ifthere is any dimension of the medication administration device that isincompatible with the device being received in the training containerwith the cap closed.

While the invention has been illustrated and described in detail in thedrawings and foregoing description, the same is to be considered asillustrative and not restrictive in character, it being understood thatonly the preferred embodiment has been shown and described and that allchanges, equivalents, and modifications that come within the spirit ofthe inventions defined by following claims are desired to be protected.All publications, patents, and patent applications cited in thisspecification are herein incorporated by reference as if each individualpublication, patent, or patent application were specifically andindividually indicated to be incorporated by reference and set forth inits entirety herein.

Various aspects are described in this disclosure, which include, but arenot limited to, the following aspects:

1. A medication delivery system including: a medication administrationdevice comprising a body having a discharge end defining a medicationdischarge port and an opposed actuator end, the medicationadministration device including a medication reservoir, the medicationadministration device further including an actuator for ejecting amedication from the reservoir through the discharge port, the actuatorextending out of the actuator end of the body, the actuator beinglinearly moveable from an extended position to a depressed position, thedischarge port being sealed when the actuator is in the extendedposition and the discharge port being open when the actuator is in thedepressed position, the actuator being operable to discharge medicationfrom the reservoir upon axial movement of the actuator from the extendedposition to the depressed position; a medication received within thereservoir of the medication administration device; a container having anaxially extending side wall and a closed bottom wall defining a cavityhaving an access opening defined by an end wall portion, the medicationadministration device being received within the cavity with thedischarge end adjacent the bottom wall of the container; and a capcoupled to the container, and movable relative to the container betweenan open position and a closed position, the cap in the closed positionsealably engaged with the container to enclose the medicationadministration device within the cavity, the cap defining one or morehold down axial projections, wherein, when the cap is in the closedposition, the one or more hold down axial projections extend axiallyfrom the cap in a direction toward the bottom wall and sized to allow atmost a predetermined amount of axial movement of the medicationadministration device in the direction away from the bottom wall,wherein the one or more hold down axial projections are contactable witha non-actuator portion of the medication administration device.

2. The medication delivery system of aspect 1 in which the one or morehold down axial projections is a rigid structure.

3. The medication delivery system of any one of aspects 1-2 in which thebody of the medication administration device includes a radiallyextending circumferential surface surrounding the actuator and facingaway from the bottom wall, wherein, when the cap is in the closedposition, the one or more hold down axial projections are positionedradially outside the actuator to be contactable against thecircumferential surface.

4. The medication delivery system of any one of aspects 1-3 in which thecap having a cup shaped body comprising a cap side wall and defining arecess configured to receive a portion of the actuator, wherein the oneor more hold down axial projections extend out beyond the recess.

5. The medication delivery system of aspect 4 in which an interiorsurface of the cap side wall and an interior surface of the one or morehold down axial projections define a continuous surface.

6. The medication delivery system of any one of aspects 1-5 wherein theone or more hold down axial projections comprises a pair of hold downaxial projections extending from the cup shaped body of the cap atradially opposite sides of the cap.

7. The medication delivery system of any one of aspects 1-6 wherein thecap includes an outer rim disposed around the cup shaped body, acircumferential flange depending axially from a bottom wall facingsurface of the outer rim, the one or more hold down axial projectionsdisposed spaced radially inward relative to the flange, and extendingaxially beyond the flange.

8. The medication delivery system of any one of aspects 1-7 in which thecap is coupled to the container by a hinged connection.

9. The medication delivery system of aspect 8 in which the hingedconnection is a living hinge.

10. The medication delivery system of aspect 8 in which the cap includestwo hold down axial projections, the two hold down projections disposedcircumferentially away from one another, the hinged connection disposedcircumferentially between the two hold down projections.

11. The medication delivery system of aspect 8 in which the cap includesa single hold down axial projection.

12. The medication delivery system of any one of aspects 1-11 in whichthe cap includes an outer rim extending radially from the cup shapedbody, and a circumferential flange depending axially from a bottom wallfacing surface of the outer rim, and the container and the cap comprisea latch member to secure the cap to the container in the closedposition, the latch member including a latch extending axially from theouter rim of the cap, wherein said flange extends axially beyond thelatch.

13. The medication delivery system of aspect 12 in which the one or morehold down axial projections of the cap comprises two hold down axialprojections, the two hold down projections disposed circumferentiallyaway from one another, the hinged connection disposed circumferentiallybetween the two hold down projections, and the latch disposedcircumferentially between the two hold down projections radiallyopposite to the hinged connection.

14. A medication delivery system including: a medication administrationdevice comprising a body having a discharge end defining a medicationdischarge port and an opposed actuator end, a medication reservoircontaining a medication, and an actuator for ejecting the medicationfrom the reservoir through the discharge port, the actuator extendingout of the actuator end of the body, the actuator being linearlymoveable from an extended position to a depressed position, thedischarge port being sealed when the actuator is in the extendedposition and the discharge port being open when the actuator is in thedepressed position, the actuator being operable to discharge medicationfrom the reservoir upon axial movement of the actuator from the extendedposition to the depressed position, wherein the body of the medicationadministration device includes a radially extending circumferentialsurface surrounding the actuator and facing away from the bottom wall;and a container comprising an axially extending side wall and a closedbottom wall defining a cavity having an access opening defined by an endwall portion, the medication administration device being received withinthe cavity with the discharge end adjacent the bottom wall of thecontainer, a cap hingedly coupled to the container, the cap movablerelative to the container between an open position and a closedposition, the cap in the closed position sealably engaged with thecontainer to enclose the medication administration device within thecavity, and a desiccant disposed within the cavity, wherein the capdefines a pair of hold down axial projections, wherein, when the cap isin the closed position, the hold down axial projections extend axiallyfrom the cap in a direction toward the bottom wall and sized to allow atmost a predetermined amount of axial movement of the medicationadministration device in the direction away from the bottom wall,wherein each of the hold down axial projections have a contact endsurface contactable with the circumferential surface of said device,radially outside the actuator of the medication administration device,wherein the hold down axial projections are configured to allow each ofthe contact end surfaces to maintain its relative axial position andradial position relative to the cap and the circumferential surface ofsaid device

15. The medication delivery system of aspect 14 in which the containerincludes a continuous inner ring disposed radially inward from aninterior surface of the side wall of the container, the inner ringaxially spaced from the bottom wall at a distance to securely retain thedesiccant between the inner ring and the bottom wall.

16. The medication delivery system of aspect 15 in which the desiccantincludes an annular notch defined along a radially outer surface of thedesiccant, the annular notch configured to receive the inner ring whenthe desiccant is disposed within the container.

17. The medication delivery system of any one of aspects 1-16 in whichthe medication administration device is an air dispersion device.

18. The medication delivery system of any one of aspects 1-17 in whichthe medication is an intranasal delivery powder.

19. The medication delivery system of aspect 18 in which the powder isglucagon.

20. A method for providing a medication delivery system containing aglucagon composition, the method including: positioning a medicationadministration device within a container, the medication administrationdevice including a body having a discharge end defining a medicationdischarge port and an opposed actuator end, the medicationadministration device including a medication reservoir containing aglucagon medication, the medication administration device furtherincluding an actuator for ejecting a medication from the reservoirthrough the discharge port, the actuator extending out of the actuatorend of the body, the actuator being linearly moveable from an extendedposition to a depressed position, the discharge port being sealed whenthe actuator is in the extended position and the discharge port beingopen when the actuator is in the depressed position, the actuator beingoperable to discharge the glucagon medication from the reservoir uponaxial movement of the actuator from the extended position to thedepressed position; the container having a side wall and a closed bottomwall defining a cavity having an access opening defined by an end wallportion, the cavity receiving the medication administration devicewithin the cavity with the discharge end adjacent the bottom wall of thecontainer; and sealing a cap to the container to provide a hermetic sealenclosing the medication administration device within the cavity, thecap defining one or more hold down axial projections positioned andconfigured to interfere with movement of the medication administrationdevice to allow at most a predetermined amount of movement of themedication administration device in the direction away from the bottomwall without the actuator contacting an axial end surface of the cap.

21. A medication container and cap assembly for containing a medicationadministration device, the medication administration device including abody having a discharge end defining a medication discharge port and anopposed actuator end, the medication administration device including amedication reservoir containing a glucagon medication, the medicationadministration device further including an actuator for ejecting theglucagon medication from the reservoir through the discharge port, theactuator extending out of the actuator end of the body, the actuatorbeing linearly moveable from an extended position to a depressedposition, the discharge port being sealed when the actuator is in theextended position and the discharge port being open when the actuator isin the depressed position, the actuator being operable to discharge theglucagon medication from the reservoir upon axial movement of theactuator from the extended position to the depressed position, theassembly including: a container having a side wall and a closed bottomwall defining a cavity having an access opening defined by an end wallportion, the cavity being sized and configured to receive the medicationadministration device, the medication administration device beingreceivable within the cavity with the discharge end adjacent the bottomwall of the container; and a cap coupled to the container by a hingedconnection, and configured to mate with the container when in a closedposition and provide a hermetic seal to enclose the medicationadministration device inserted within the cavity, the cap defining apair of hold down members positioned and configured to interfere withmovement of the medication administration device to allow at most apredetermined amount of movement of the medication administration devicein the direction away from the bottom wall, the hold down membersdisposed circumferentially away from one another, the hinge connectiondisposed circumferentially between the two hold down members.

22. The assembly of aspect 21 in which the container side wall is sizedto allow an end portion of the actuator to extend out beyond thecontainer side wall through the open end of the container, the caphaving a cup-shaped body defining a recess configured to receive the endportion of the actuator, wherein an interior surface of the cup-shapedbody that faces the recess and an interior surface of each of the holddown members where the hold down members extend from the cup-shaped bodydefine a continuous surface.

23. The assembly of aspect 22 in which the desiccant is configured tofit within the container adjacent the bottom wall, the desiccantincluding an annular shaped body with a central cavity configured toreceive the medication discharge port of the medication administrationdevice therein, the container including an inner ring disposed radiallyfrom an interior surface of the side wall of the container, and thedesiccant includes an annular notch defined along a radially outer endof the annular shaped body that faces away from the bottom wall, theannular notch configured to receive the inner ring when the desiccant isdisposed within the container.

24. A training module for use in a medication delivery system including:a training module including a body having a discharge end defining asimulated medication discharge port and an opposed actuator endincluding a simulated actuator, the actuator extending out of theactuator end of the body, a training container having a side wall and aclosed bottom wall defining a cavity having an access opening defined byan end wall portion, the cavity being sized and configured to receivethe training module, the training module being received within thecavity with the discharge end adjacent the bottom wall of the container;and a training cap hingedly attached to the training container, thetraining cap mating with the training container and enclosing thetraining module within the cavity, the training cap defining one or morehold down members positioned and configured to interfere with movementof the training module to allow at most a predetermined amount ofmovement of the training module in the direction away from the bottomwall, each of the one or more hold down members including a projectionextending from the training cap in a direction toward the bottom wall.

25. A medication delivery system including: a medication administrationdevice including a body having a discharge end defining a medicationdischarge port and an opposed actuator end, the medicationadministration device including a medication reservoir, the medicationadministration device further including an actuator for ejecting amedication from the reservoir through the discharge port, the actuatorextending out of the actuator end of the body, the actuator beinglinearly moveable from an extended position to a depressed position, thedischarge port being sealed when the actuator is in the extendedposition and the discharge port being open when the actuator is in thedepressed position, the actuator being operable to discharge medicationfrom the reservoir upon axial movement of the actuator from the extendedposition to the depressed position; medication received within thereservoir of the medication administration device; a product containerhaving a side wall and a closed bottom wall defining a cavity having anaccess opening defined by an end wall portion, the cavity being sizedand configured to receive the medication administration device, themedication administration device being received within the cavity withthe discharge end adjacent the bottom wall of the container; a productcap attached to the container, the product cap mating with the containerand providing a hermetic seal enclosing the medication administrationdevice within the cavity, the product cap defining one or more hold downmembers positioned and configured to interfere with movement of themedication administration device to allow at most a predetermined amountof movement of the medication administration device in the directionaway from the bottom wall, each of the one or more hold down membersincluding a projection extending from the cap in a direction toward thebottom wall, a training module including a body having a discharge enddefining a simulated medication discharge port and an opposed actuatorend including a simulated actuator, the simulated actuator extending outof the actuator end of the body of the training module, a trainingcontainer having a side wall and a closed bottom wall defining a cavityhaving an access opening defined by an end wall portion, the cavitybeing sized and configured to receive the training module, the trainingmodule being received within the cavity with the discharge end adjacentthe bottom wall of the container; and a training cap attached to thetraining container, the training cap mating with the training containerand enclosing the training module within the cavity, the training capdefining one or more hold down members positioned and configured tointerfere with movement of the training module to allow at most apredetermined amount of movement of the training module in the directionaway from the bottom wall, each of the one or more hold down membersincluding a projection extending from the training cap in a directiontoward the bottom wall, the medication delivery device including adimension that is incompatible with it being received within thetraining container with the training cap closed.

26. The medication delivery system of aspect 25 in which the trainingmodule includes a dimension that is incompatible with it being receivedwithin the product container with the product cap closed.

What is claimed is:
 1. A medication delivery system comprising: amedication administration device comprising a body having a dischargeend defining a medication discharge port and an opposed actuator end,the medication administration device including a medication reservoir,the medication administration device further including an actuator forejecting a medication from the reservoir through the discharge port, theactuator extending out of the actuator end of the body, the actuatorbeing linearly moveable from an extended position to a depressedposition, the discharge port being sealed when the actuator is in theextended position and the discharge port being open when the actuator isin the depressed position, the actuator being operable to discharge themedication from the reservoir upon axial movement of the actuator fromthe extended position to the depressed position; said medicationreceived within the reservoir of the medication administration device; acontainer having an axially extending side wall and a closed bottom walldefining a cavity having an access opening defined by an end wallportion, the medication administration device being received within thecavity with the discharge end adjacent the closed bottom wall of thecontainer, and a desiccant disposed within the cavity, the desiccanthaving an annular shape to define an opening to receive the medicationdischarge port of the medication administration device, in which thecontainer includes a continuous interior shoulder disposed radiallyinward from an interior surface of the axially extending side wall, thecontinuous interior shoulder axially spaced from the closed bottom wallat a distance to securely retain the desiccant between the continuousinterior shoulder and the closed bottom wall, in which the desiccantincludes an annular notch defined along a radially outer surface of thedesiccant, the annular notch configured to receive the continuousinterior shoulder when the desiccant is disposed within the container;and a cap coupled to the container, and movable relative to thecontainer between an open position and a closed position, the cap in theclosed position is sealably engaged with the container to enclose themedication administration device within the cavity, the cap defining oneor more hold down members, wherein, when the cap is in the closedposition, the one or more hold down members extends axially from the capin a direction toward the closed bottom wall and is sized to allow atmost a predetermined amount of axial movement of the medicationadministration device in the direction away from the closed bottom wall,wherein the one or more hold down members is contactable with anon-actuator portion of the medication administration device.
 2. Themedication delivery system of claim 1 in which the one or more hold downmembers is a rigid structure.
 3. The medication delivery system of claim2 in which the body of the medication administration device includes aradially extending circumferential surface surrounding the actuator andfacing away from the closed bottom wall, wherein, when the cap is in theclosed position, the one or more hold down members is positionedradially outside the actuator to be contactable against thecircumferential surface.
 4. The medication delivery system of claim 3 inwhich the cap having a cup shaped body comprising a cap side wall anddefining a recess configured to receive a portion of the actuator,wherein the one or more hold down axial members extends out beyond therecess.
 5. The medication delivery system of claim 4 in which aninterior surface of the cap side wall and an interior surface of the oneor more hold down members define a continuous surface.
 6. The medicationdelivery system of claim 4 wherein the one or more hold down memberscomprises a pair of hold down axial projections extending from the cupshaped body of the cap at radially opposite sides of the cap.
 7. Themedication delivery system of claim 4 wherein the cap includes an outerrim disposed around the cup shaped body, a circumferential flangedepending axially from a bottom wall facing surface of the outer rim,the one or more hold down members disposed spaced radially inwardrelative to the flange, and extending axially beyond the flange.
 8. Themedication delivery system of claim 2 in which the cap is coupled to thecontainer by a hinged connection.
 9. The medication delivery system ofclaim 8 in which the hinged connection is a living hinge.
 10. Themedication delivery system of claim 8 in which the one or more holdmembers includes two hold down members, the two hold down membersdisposed circumferentially away from one another, the hinged connectiondisposed circumferentially between the two hold down members.
 11. Themedication delivery system of claim 8 in which the one or more holdmembers includes a single hold down member.
 12. The medication deliverysystem of claim 3 in which the cap includes an outer rim extendingradially from the cup shaped body, and a circumferential flangedepending axially from a bottom wall facing surface of the outer rim,and the container and the cap comprise a latch member to secure the capto the container in the closed position, the latch member including alatch extending axially from the outer rim of the cap, wherein saidflange extends axially beyond the latch.
 13. The medication deliverysystem of claim 12 in which the one or more hold down members of the capcomprises two hold down members, the two hold down members disposedcircumferentially away from one another, the hinged connection disposedcircumferentially between the two hold down members, and the latchdisposed circumferentially between the two hold down members radiallyopposite to the hinged connection.
 14. A medication delivery systemcomprising: a medication administration device comprising a body havinga discharge end defining a medication discharge port and an opposedactuator end, a medication reservoir containing a medication, and anactuator for ejecting the medication from the reservoir through thedischarge port, the actuator extending out of the actuator end of thebody, the actuator being linearly moveable from an extended position toa depressed position, the discharge port being sealed when the actuatoris in the extended position and the discharge port being open when theactuator is in the depressed position, the actuator being operable todischarge said medication from the reservoir upon axial movement of theactuator from the extended position to the depressed position; and acontainer comprising an axially extending side wall and a closed bottomwall defining a cavity having an access opening defined by an end wallportion, the medication administration device being received within thecavity with the discharge end adjacent the bottom wall of the container,a cap hingedly coupled to the container, the cap movable relative to thecontainer between an open position and a closed position, the cap in theclosed position is sealably engaged with the container to enclose themedication administration device within the cavity, and a desiccantdisposed within the cavity, the desiccant having an annular shape todefine an opening to receive the medication discharge port of themedication administration device, wherein the body of the medicationadministration device includes a radially extending circumferentialsurface surrounding the actuator and facing away from the closed bottomwall, in which the container includes a continuous interior shoulderdisposed radially inward from an interior surface of the axiallyextending side wall of the container, the continuous interior shoulderaxially spaced from the closed bottom wall at a distance to securelyretain the desiccant between the continuous interior shoulder and theclosed bottom wall, in which the desiccant includes an annular notchdefined along a radially outer surface of the desiccant, the annularnotch configured to receive the continuous interior shoulder when thedesiccant is disposed within the container, wherein the cap defines apair of hold down members, wherein, when the cap is in the closedposition, the hold down members extend axially from the cap in adirection toward the closed bottom wall and sized to allow at most apredetermined amount of axial movement of the medication administrationdevice in the direction away from the closed bottom wall, wherein eachof the hold down members has a contact end surface contactable with thecircumferential surface of said medication administration device,radially outside the actuator of the medication administration device,wherein the hold down members are configured to allow each of thecontact end surfaces to maintain its relative axial position and radialposition relative to the cap and the circumferential surface of saiddevice.
 15. The medication delivery system of claim 14 in which themedication administration device is an air dispersion device.
 16. Themedication delivery system of claim 15 in which the medication is anintranasal delivery powder.
 17. The medication delivery system of claim16 in which the powder is glucagon.
 18. A method for providing amedication delivery system containing a glucagon composition, the methodcomprising: positioning a medication administration device within acontainer, the medication administration device comprising a body havinga discharge end defining a medication discharge port and an opposedactuator end, the medication administration device including amedication reservoir containing a glucagon medication, the medicationadministration device further including an actuator for ejecting saidglucagon medication from the reservoir through the discharge port, theactuator extending out of the actuator end of the body, the actuatorbeing linearly moveable from an extended position to a depressedposition, the discharge port being sealed when the actuator is in theextended position and the discharge port being open when the actuator isin the depressed position, the actuator being operable to discharge theglucagon medication from the reservoir upon axial movement of theactuator from the extended position to the depressed position; thecontainer having a side wall and a closed bottom wall defining a cavityhaving an access opening defined by an end wall portion, the cavityreceiving the medication administration device within the cavity withthe discharge end adjacent the closed bottom wall of the container, anda desiccant disposed within the cavity, the desiccant having an annularshape to define an opening to receive the medication discharge port ofthe medication administration device, in which the container includes acontinuous interior shoulder disposed radially inward from an interiorsurface of the side wall, the continuous interior shoulder axiallyspaced from the closed bottom wall at a distance to securely retain thedesiccant between the continuous interior shoulder and the closed bottomwall, in which the desiccant includes an annular notch defined along aradially outer surface of the desiccant, the annular notch configured toreceive the continuous interior shoulder when the desiccant is disposedwithin the container; and sealing a cap to the container to provide ahermetic seal enclosing the medication administration device within thecavity, the cap defining one or more hold down members positioned andconfigured to interfere with movement of the medication administrationdevice to allow at most a predetermined amount of movement of themedication administration device in the direction away from the closedbottom wall without the actuator contacting an axial end surface of thecap.
 19. A medication container and cap assembly for containing amedication administration device, the medication administration devicecomprising a body having a discharge end defining a medication dischargeport and an opposed actuator end, the medication administration deviceincluding a medication reservoir containing a medication, the medicationadministration device further including an actuator for ejecting themedication from the reservoir through the discharge port, the actuatorextending out of the actuator end of the body, the actuator beinglinearly moveable from an extended position to a depressed position, thedischarge port being sealed when the actuator is in the extendedposition and the discharge port being open when the actuator is in thedepressed position, the actuator being operable to discharge themedication from the reservoir upon axial movement of the actuator fromthe extended position to the depressed position, the assemblycomprising: a container having a side wall and a closed bottom walldefining a cavity having an access opening defined by an end wallportion, the cavity being sized and configured to receive the medicationadministration device, the medication administration device beingreceivable within the cavity with the discharge end adjacent the closedbottom wall of the container, and a desiccant disposed within thecavity, the desiccant having an annular shape to define an opening toreceive the medication discharge port of the medication administrationdevice, in which the container includes a continuous interior shoulderdisposed radially inward from an interior surface of the side wall, thecontinuous interior shoulder axially spaced from the closed bottom wallat a distance to securely retain the desiccant between the continuousinterior shoulder and the closed bottom wall, in which the desiccantincludes an annular notch defined along a radially outer surface of thedesiccant, the annular notch configured to receive the continuousinterior shoulder when the desiccant is disposed within the container;and a cap coupled to the container by a hinged connection, andconfigured to mate with the container when in a closed position andprovide a hermetic seal to enclose the medication administration deviceinserted within the cavity, the cap defining a pair of hold down memberspositioned and configured to interfere with movement of the medicationadministration device to allow at most a predetermined amount ofmovement of the medication administration device in the direction awayfrom the closed bottom wall, the hold down members disposedcircumferentially away from one another, the hinge connection disposedcircumferentially between the two hold down members.
 20. The assembly ofclaim 19 in which the container side wall is sized to allow an endportion of the actuator to extend out beyond the container side wall,the cap having a cup shaped body defining a recess configured to receivethe end portion of the actuator, each of the hold down members extendingfrom the cup shaped body, wherein an interior surface of the cup shapedbody that faces the recess and an interior surface of the hold downmembers define a continuously smooth surface.
 21. The medicationdelivery system of claim 1 in which the medication administration deviceis an air dispersion device.
 22. The medication delivery system of claim21 in which the medication is an intranasal delivery powder.
 23. Themedication delivery system of claim 22 in which the powder is glucagon.